๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Bioavailability of microsize and ultramicrosize griseofulvin products in man

โœ Scribed by Arthur B. Straughn; Marvin C. Meyer; Gursharan Raghow; Keith Rotenberg


Book ID
112472364
Publisher
Springer
Year
1980
Tongue
English
Weight
750 KB
Volume
8
Category
Article
ISSN
1573-8744

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๐Ÿ“œ SIMILAR VOLUMES


Absorption kinetics of griseofulvin in m
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The distribution and elimination kinetics of griseofulvin have been examined in man. T h e drug was administered intravenously in polyethylene glycol 300 via a saline drip. The plasma-concentration time cuwe was satisfactorily described by a bi-exponential equation, the half-life for the first expon

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## RISEOFULVIN is given in large amounts and is Its dose in man is 12.5-500 mg., and its water solubility is 15 mcg./ml. at 37'. If the digestive fluids are saturated with respect to griseofulvin at all times, and griseo-

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## Abstract Fourteen normal male subjects were given either 60 mg or 180mg of terfenadine suspension in a randomized twoโ€way crossover study. Peak plasma concentrations of 1.544 ยฑ 0.726 (mean ยฑ S.D.) ng ml^โˆ’1^ were obtained in 0.786 ยฑ 0.426 h following the 60 mg dose and displayed an AUC of 11.864

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Ten healthy male volunteers received single oral doses of l00mg of medroxalol administered as a solution, a preliminary tablet formulation and a single dose of lOOmg administered intravenously in a randomized three-way crossover study. Mean terminal half-lives of 12.4, 13.4, and 11.3 h were observed