Bioavailability of microsize and ultramicrosize griseofulvin products in man
โ Scribed by Arthur B. Straughn; Marvin C. Meyer; Gursharan Raghow; Keith Rotenberg
- Book ID
- 112472364
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 750 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1573-8744
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The distribution and elimination kinetics of griseofulvin have been examined in man. T h e drug was administered intravenously in polyethylene glycol 300 via a saline drip. The plasma-concentration time cuwe was satisfactorily described by a bi-exponential equation, the half-life for the first expon
## RISEOFULVIN is given in large amounts and is Its dose in man is 12.5-500 mg., and its water solubility is 15 mcg./ml. at 37'. If the digestive fluids are saturated with respect to griseofulvin at all times, and griseo-
## Abstract Fourteen normal male subjects were given either 60 mg or 180mg of terfenadine suspension in a randomized twoโway crossover study. Peak plasma concentrations of 1.544 ยฑ 0.726 (mean ยฑ S.D.) ng ml^โ1^ were obtained in 0.786 ยฑ 0.426 h following the 60 mg dose and displayed an AUC of 11.864
Ten healthy male volunteers received single oral doses of l00mg of medroxalol administered as a solution, a preliminary tablet formulation and a single dose of lOOmg administered intravenously in a randomized three-way crossover study. Mean terminal half-lives of 12.4, 13.4, and 11.3 h were observed