Bioanalytical applications of ‘fast chromatography’ to high-throughput liquid chromatography/tandem mass spectrometric quantitation
✍ Scribed by Leslie Romanyshyn; Philip R. Tiller; Cornelis E. C. A. Hop
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 116 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0951-4198
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A simple and sensitive method is described for the determination of E5880 in rat plasma. The method is based on high-performance liquid chromatography/electrospray ionization mass spectrometry, using deuterated E5880 as an internal standard. Selected reaction monitoring is employed for selectivity a
Fast gradient capillary high performance liquid chromatography (HPLC) coupled to a mass spectrometer has been successfully used for the analysis of pharmaceutical compounds from biological matrices, in the femtogram on column range. In the work reported in this paper, the use of capillary HPLC, on t
This work describes a new method for the quantitation of trace amounts of sulfamethazine (SMZ) and its main metabolite, N4-acetylsulfamethazine (Ac-SMZ), in swine urine, using high-performance liquid chromatography (HPLC) tandem mass spectrometric analysis of crude urine after addition of internal s
A liquid chromatography tandem mass spectrometry (LC/MS/MS) method has been developed for the fast routine analysis of selected CYP450 probe substrate metabolites in microsomal incubations, with no sample pretreatment. This has allowed fast and simple assessment of the potential effects which drug c