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Binding, Uptake and Degradation of the Toxic Proteins Abrin and Ricin by Toxin-Resistant Cell Variants

โœ Scribed by Kirsten SANDVIG; Sjur OLSNES; Alexander PIHL

Book ID
115116407
Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
894 KB
Volume
82
Category
Article
ISSN
1432-1327

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Properties and action mechanism of the toxic lectin modeccin: Interaction with cell lines resistant to modeccin, abrin, and ricin
โœ Olsnes, Sjur ;Sandvig, Kirsten ;Eiklid, Kristin ;Pihl, Alexander ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 604 KB

The toxic lectin modeccin, which inhibits protein synthesis in eukaryotic cells, is cleaved upon treatment with 2-mercaptoethanol into two peptide chains which move in polyacrylamide gels at rates corresponding to molecular weights 28,000 and 38,000. After reduction, the toxin loses its effect on ce