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Binding of Wild-Type P53 by Topoisomerase II and Overexpression of Topoisomerase II in Human Hepatocellular Carcinoma

✍ Scribed by Hao Yuwen; Chu Chieh Hsia; Yutaka Nakashima; Amy Evangelista; Edward Tabor

Book ID
115580174
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
327 KB
Volume
234
Category
Article
ISSN
0006-291X

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The p53 null HL-60 cell line was transfected with plasmids coding for either the wild-type p53 or mutant p53 gene. The stable expression of wild-type p53 resulted in a significant increase in sensitivity to the topoisomerase II poisons etoposide and doxorubicin, but not to the topoisomerase II inhib