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Human Topoisomerase IIα and IIβ Interact with the C-Terminal Region of p53

✍ Scribed by Ian G. Cowell; Andrei L. Okorokov; Sarah A. Cutts; Kay Padget; Margaret Bell; Jo Milner; Caroline A. Austin


Book ID
115603573
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
339 KB
Volume
255
Category
Article
ISSN
0014-4827

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The p53 null HL-60 cell line was transfected with plasmids coding for either the wild-type p53 or mutant p53 gene. The stable expression of wild-type p53 resulted in a significant increase in sensitivity to the topoisomerase II poisons etoposide and doxorubicin, but not to the topoisomerase II inhib