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Binding of two distamycin A molecules in the minor groove of an alternating B–DNA duplex

✍ Scribed by Chen, Xin; Ramakrishnan, Boopathy; Rao, Sambhorao T.; Sundaralingam, Muttaiya


Book ID
109964615
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
766 KB
Volume
1
Category
Article
ISSN
1072-8368

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Accessibility of the minor groove of DNA
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The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared wit