Binding of the anticancer alkaloid sanguinarine with tRNA phe : spectroscopic and calorimetric studies
β Scribed by Hossain, Maidul; Kabir, Ayesha; Suresh Kumar, Gopinatha
- Book ID
- 127076115
- Publisher
- Adenine Press
- Year
- 2012
- Tongue
- English
- Weight
- 679 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0739-1102
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π SIMILAR VOLUMES
Sanguinarine is a medically important plant alkaloid with remarkable pharmacological and biological activities. DNA binding is considered to be an important aspect in its mode of action. Isothermal titration calorimetric technique was used for the first time to derive the thermodynamic aspects of th
The interaction of two natural protoberberine plant alkaloids berberine and palmatine with tRNA phe was studied using various biophysical techniques and molecular modeling and the data were compared with the binding of the classical DNA intercalator, ethidium. Circular dichroic studies revealed that