Binding of Pyrimethamine to Human Plasma Proteins and Erythrocytes
β Scribed by Anita C. Rudy; Wesley J. Poynor
- Book ID
- 110343587
- Publisher
- Springer US
- Year
- 1990
- Tongue
- English
- Weight
- 1003 KB
- Volume
- 07
- Category
- Article
- ISSN
- 0724-8741
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The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and β£1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 Β± 5.5%, 83.8 Β± 5.2%, and 75
The in vitro binding of RS-chlorpheniramine to human proteins was studied by equilibrium dialysis. The binding to total plasma proteins and to individual albumin and β£-glycoprotein acid is stereoselective. (+)S-chlorpheniramine is more extensively bound than its antipode to total plasma proteins (38