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Binding of nonsteroidal anti-inflammatory agents to proteins—I. Ibuprofen-serum albumin interaction

✍ Scribed by John B. Whitlam; Michael J. Crooks; Kenneth F. Brown; Peter Veng Pedrrsen

Book ID
115774429
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
450 KB
Volume
28
Category
Article
ISSN
0006-2952

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Structural requirements for binding of nonsteroidal anti-inflammatory drugs to human serum albumin
✍ Kim L. Li; Ajit K. Thakur; Amrit L. Kapoor 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 541 KB

The binding of representative chemical classes of nonsteroidal anti-inflammatory drugs (NSAIDs) to human serum albumin (HSA) was investigated by equilibrium dialysis. Warfarin enantiomers were used as specific markers in displacement studies. Data were analyzed by a computerized nonlinear least squa