Binding of Antithrombin III and Thrombin to Immobilized Heparin under Flow Conditions
β Scribed by Youngro Byun; Harvey A. Jacobs; Sung Wan Kim
- Book ID
- 109387827
- Publisher
- American Institute of Chemical Engineers
- Year
- 1996
- Tongue
- English
- Weight
- 239 KB
- Volume
- 12
- Category
- Article
- ISSN
- 8756-7938
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π SIMILAR VOLUMES
An objective of this research is to verify the mechanism of anticoagulant activity of surface-immobilized heparin in the presence of plasma proteins. The competition and binding interaction between immobilized heparin and antithrombin I11 (ATIII)/thrombin have been described in vituo. However, the s
Three types of immobilized heparin, heparin-Sepharoses I, II, and III, were prepared to study the effect of the mode of the heparin attachment on the binding activities to thrombin and antithrombin III (AT-III). Heparin-Sepharose I was prepared by the coupling of the car-boxy1 groups of heparin with
## Ontario M5S IA4, Caiiadu The diffusivities of thrombin and antithrombin I11 in a heparin-polyvinyl alcohol hydrogel were estimated and used to demonstrate that diffusion limits the effectiveness of the immobilized heparin in the interior of such hydrogels. Diffusivities were calculated from per
End-point immobilization of heparin to artificial activity in contact with plasma, either on the exposed surfaces materials gives rise to a surface that prevents triggering of or in the plasma phases. Below this level, the degree of the plasma contact activation system and, presumably as a activatio