Inhibition of the plasma contact activation system of immobilized heparin: Relation to surface density of functional antithrombin binding sites
✍ Scribed by S�nchez, J. ;Elgue, G. ;Riesenfeld, J. ;Olsson, P.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 208 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
End-point immobilization of heparin to artificial activity in contact with plasma, either on the exposed surfaces materials gives rise to a surface that prevents triggering of or in the plasma phases. Below this level, the degree of the plasma contact activation system and, presumably as a activation gradually increased with decreasing densities, and result thereof, generally has thrombo-resistant properties.
in parallel the thrombo-resistant properties deteriorated. Ad-The present investigation was undertaken to determine what dition of heparin to the plasma phase reduced the capacity density of immobilized heparin molecules expressing func-of the heparin surfaces to bind antithrombin, leading to a tionally intact antithrombin binding sites is required to diminished ability of the surfaces to prevent contact activaachieve these blood compatible properties. Six different hep-tion. This finding supports the hypothesis that antithrombin arin surfaces were prepared on polyethylene tubing and is the critical coagulation inhibitor for the suppression of studied in contact with human plasma. The content of bound contact activation on end-point immobilized heparin. © 1997 heparin was the same on all surfaces while the densities of