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Binding of antiarrhythmic drugs to purified human α1-acid glycoprotein

✍ Scribed by Anne M. Gillis; Yin-Gail Yee; Robert E. Kates


Book ID
115778216
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
431 KB
Volume
34
Category
Article
ISSN
0006-2952

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The binding of the anticoagulant drug phenprocoumon to bovine and human a 1 -acid glycoprotein (AGP) was studied using a fluorescence titration technique. Phenprocoumon was found to have one moderate strength binding site on bovine AGP with n Å (0.78 { 0.04) and a Scatchard association constant, K Å