These experiments were designed to test the ability of certain analogs and metabolites of all-transretinoic acid (RA), 13-cis-retinoic acid, 4-hydroxy-alltrans-retinoic acid, 4-keto-all-trans-retinoic acid, trimethylmethoxyphenol (TMMP) analog of retinoic acid, and TMMP analog of ethyl retinoate (et
Binding of all-trans-retinoic acid to MLTC-1 proteins
β Scribed by Erika Cione; Paola Tucci; Valentina Senatore; Giuseppina Ioele; Giuseppe Genchi
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 600 KB
- Volume
- 276
- Category
- Article
- ISSN
- 0300-8177
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## Abstract The present study examined the effects of allβ__trans__ retinoic acid (tRA) on proliferation and expression of the IGF system in Cacoβ2 human colon adenocarcinoma cells. tRA inhibited Cacoβ2 cell proliferation in a doseβdependent manner, with a 40βΒ±β2% decrease in cell number observed 4
All-trans-retinoyl-beta-D-glucuronide (all-trans-RAG) is a water-soluble derivative of all-trans-retinoic acid (all-trans-RA) and has been characterized as an endogenous metabolite of vitamin A in rat bile and kidney. All-trans-RAG was previously demonstrated to be a major metabolite after applicati