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Binding of a new multidrug resistance modulator, S9788, to human plasma proteins and erythrocytes

✍ Scribed by Saïk Urien; Phuc Nguyen; Gérard Bastian; Catherine Lucas; Jean-Paul Tillement


Book ID
110591279
Publisher
Springer US
Year
1995
Tongue
English
Weight
356 KB
Volume
13
Category
Article
ISSN
0167-6997

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BINDING CHARACTERISTICS OF KNI-272 TO PL
✍ A. Kiriyama; T. Nishiura; M. Ishino; Y. Yamamoto; I. Ogita; Y. Kiso; K. Takada 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 690 KB

The binding characteristics of KNI-272, a potent and selective human immunodeficiency virus (HIV) protease inhibitor, were evaluated in rat and human plasma, and in solutions of human a,-acid glycoprotein (AAG) and human serum albumin (HSA). The unbound fractions (F,) of KNI-272 were 12.13 and 2.24%