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Binding of a fibrinogen mimetic stabilizes integrin αIIbβ3's open conformation

✍ Scribed by Roy R. Hantgan; Mattia Rocco; Chandrasekaran Nagaswami; John W. Weisel

Book ID
111753318
Publisher
Cold Spring Harbor Laboratory Press
Year
2001
Tongue
English
Weight
500 KB
Volume
10
Category
Article
ISSN
0961-8368

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📜 SIMILAR VOLUMES

Binding of fibrinogen to platelet integr
Binding of fibrinogen to platelet integrin αIIbβ3 in solution as monitored by tracer sedimentation equilibrium
✍ Germán Rivas; Kirsten Tangemann; Allen P. Minton; Jürgen Engel 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 864 KB

Fibrinogen showed essentially no binding (KD> 1 mM) to platelet aIIb@ integrin in solution in the presence of Triton or octylglucoside above critical micellar concentrations. Under these conditions the integrin was an a$ monomer. After removal of the detergent from the Triton containing buffer (25 m