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Fibrinogen and prothrombin binding is enhanced to the Pro33 isoform of purified integrin αIIbβ3

✍ Scribed by K. V. VIJAYAN; Y. LIU; S. SOUZA; P. THIAGARAJAN; P. F. BRAY


Book ID
109151447
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
141 KB
Volume
4
Category
Article
ISSN
1538-7933

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✍ Germán Rivas; Kirsten Tangemann; Allen P. Minton; Jürgen Engel 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 864 KB

Fibrinogen showed essentially no binding (KD> 1 mM) to platelet aIIb@ integrin in solution in the presence of Triton or octylglucoside above critical micellar concentrations. Under these conditions the integrin was an a$ monomer. After removal of the detergent from the Triton containing buffer (25 m