Experimental factors and determinants of the protein binding of enoximone (a new cardiotonic agent) were investigated in human serum from healthy, drug-free subjects using a rapid ultrafiltration method; these factors and determinants included nonspecific binding to the apparatus, ultrafiltrate volu
Binding of 5,5-diphenylhydantoin and its major metabolite to human and rat plasma proteins
β Scribed by Gordon J. Conard; Coryce O. Haavik; Kenneth F. Finger
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 602 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A simple and convenient method for the synthesis of carbonβ^14^ labeled diphenylhydantoin (DPH) (I) and its major metabolite 5β(pβhydroxyphenyl)β5βphenylhydantoin (HPPH) (II) in 70 minutes is described. This synthesis allows incorporation of carbonβ11β^11^ (physical halfβlife 20 minutes
The aim of this study was to determine in vitro protein binding of tolterodine and its 5-hydroxymethyl (5-HM) and N-dealkylated metabolites in serum from humans and several animal species at concentrations similar to those obtained in clinical and preclinical studies. Binding of tolterodine and the
The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and β£1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 Β± 5.5%, 83.8 Β± 5.2%, and 75