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Binding of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) to protein- and low molecular weight thiols and its role in ring hydroxylation

✍ Scribed by Jan Alexander; Ragnhild Reistad; Henrik Frandsen; Spiros Grivas

Book ID
114071224
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
192 KB
Volume
376
Category
Article
ISSN
0027-5107

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## 2-Amino -1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic aromatic amine found in cooked meat. It is metabolically activated by the human cytochrome P450 enzymes to form the carcinogenic metabolite N 2 -OH-PhIP. PhIP has been found to induce tumors in rats and is