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Binding and regulation of HIF-1α by a subunit of the proteasome complex, PSMA7

✍ Scribed by Sayeon Cho; Youn-Jeong Choi; Jeong-Min Kim; Seong-Tae Jeong; Jae-Hoon Kim; Seung-Ho Kim; Seong-Eon Ryu


Book ID
117103053
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
192 KB
Volume
498
Category
Article
ISSN
0014-5793

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Hypoxia inducible factor-1a (HIF-1a) stimulates expression of genes associated with angiogenesis and is associated with poor outcomes in ovarian and other cancers. In normoxia, HIF-1a is ubiquitinated and degraded through the E3 ubiquitin ligase, von Hippel-Lindau; however, little is known about the