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Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab

✍ Scribed by Nicholas Papadopoulos; Joel Martin; Qin Ruan; Ashique Rafique; Michael P. Rosconi; Ergang Shi; Erica A. Pyles; George D. Yancopoulos; Neil Stahl; Stanley J. Wiegand


Book ID
113060348
Publisher
Springer
Year
2012
Tongue
English
Weight
356 KB
Volume
15
Category
Article
ISSN
0969-6970

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Background. Vascular endothelial growth factor (VEGF) is a specific endothelial cell mitogen that stimulates angiogenesis and plays a crucial role in tumor growth. The aim of the present study was to evaluate the expression of VEGF and of its two high-affinity tyrosine kinase receptors (KDR and Flt-