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BIM is a novel regulator of glucocorticoid-induced apoptosis in osteoblasts

✍ Scribed by B. Espina; R.G.G. Russell; P. Hulley


Book ID
116319519
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
53 KB
Volume
38
Category
Article
ISSN
8756-3282

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Regulation of bim in glucocorticoid-medi
✍ B. Espina; M. Liang; R.G.G. Russell; P.A. Hulley πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 335 KB

## Abstract Osteoblasts undergo apoptosis both in vitro and in vivo in response to high dose glucocorticoid (GC) treatment. However, the molecular mechanisms remain elusive, hindering the prevention and treatment of this side‐effect. Apoptosis was induced by dexamethasone (Dex) in murine MBA‐15.4 o