Prevention of Glucocorticoid-Induced Apoptosis in Osteocytes and Osteoblasts by Calbindin-D28k
β Scribed by Yan Liu; Angela Porta; Xiaorong Peng; Kristen Gengaro; Earlene B Cunningham; Hong Li; Luis A Dominguez; Teresita Bellido; Sylvia Christakos
- Book ID
- 111485004
- Publisher
- American Society for Bone and Mineral Research
- Year
- 2003
- Tongue
- English
- Weight
- 807 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0884-0431
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## Abstract ## Objective Endogenous glucocorticoids (GCs) modulate numerous biologic systems involved in the initiation and maintenance of arthritis. Bone cells play a critical role in the progression of arthritis, and some of the effects of GCs on inflammation may be mediated via these cells. The
## Abstract Calcium (Ca^2+^) is an important regulator of apoptotic signaling. CalbindinβD~9k~ (CaBPβ9k) and βD~28k~ (CaBPβ28k) have a high affinity for Ca^2+^ ions. Uterine calbindins appear to be involved in the regulation of myometrial activity by intracellular Ca^2+^. In addition, uterine calbi