Glucuronidation is the major pathway for elimination of acetaminophen, diverting it from the toxifying pathway catalyzed by cytochromes P-450. A genetic deficiency in bilirubin UDP-glucuronyl transferase may predispose humans and animals to the toxicity of drugs that are extensively glucuronidated,
Bilirubin toxicity: Outcome in infants with high bilirubin levels
✍ Scribed by Nihal Oygür; N. Gygür; D. Nuzumlali; A. Ersay; S. Velipasaojuvylu; O. Yejuvyin
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 259 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0340-6997
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Sixty-seven babies were utilized to (a) document the serum bilirubin lowering effect and safety of a phenobarbitone and nikethamide combination in neonatal hyperbilirubinaemia of non-hemolytic origin; (b) determine whether birthweight and/or SGOT, SGPT or SGGT activity on day one of life correlated
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