Hepatic enzymes, their induction and usefulness in predicting maximal serum bilirubin levels in premature newborn infants
✍ Scribed by H. Bartels; A. Fenner; W. Merwe; S. Barbalatt; J. Wolfsdorf
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 301 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0340-6997
No coin nor oath required. For personal study only.
✦ Synopsis
Sixty-seven babies were utilized to (a) document the serum bilirubin lowering effect and safety of a phenobarbitone and nikethamide combination in neonatal hyperbilirubinaemia of non-hemolytic origin; (b) determine whether birthweight and/or SGOT, SGPT or SGGT activity on day one of life correlated with the maximum serum bilirubin level achieved; and (c) investigate the pattern of hepatic enzyme levels in serum under normal conditions anf following drug induction. Results indicate a significantly lower serum bilirubin level in the treated group of babies. Birthweight and day one SGGT levels, and SGGT/birthweight ratio correlated well with the maximum serum bilirubin reached, the latter ratio being particularly useful in predicting the degree of hyperbilirubinaemia.