✦ LIBER ✦

Bile composition in patients with ileal resection due to Crohn's disease

✍ Scribed by Dr. Annika Lapidus; Curt Einarsson

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 562 KB
Volume: 4
Category: Article
ISSN: 1078-0998
DOI: 10.1002/ibd.3780040204

No coin nor oath required. For personal study only.

✦ Synopsis

Patients with Crohn's disease (CD) have an increased risk of developing gallstones, but the mechanisms are unknown. In a previous study, we found a subnormal cholesterol saturation in the bile of patients with short ileal resections due to CD. The aim of this study was to test the hypothesis that (a) CD patients with a long ileal resection have an altered biliary composition and (b) that CD patients with short or long ileal resection have an increased content of bilirubin in their bile. Biliary lipid composition, cholesterol saturation, bile acid pattern, and bilirubin concentration were determined in fasting duodenal bile of 10 CD patients with long ileal resections and in 4 patients with short resections. Ten healthy subjects served as controls. Cholesterol saturation was significantly lower in

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