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Bile acids in cholestasis: Bad for the liver, not so good for the kidney

✍ Scribed by Erlinger, Serge


Book ID
122810129
Publisher
Elsevier
Year
2014
Tongue
French
Weight
351 KB
Volume
38
Category
Article
ISSN
2210-7401

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NorUDCA (24-norursodeoxycholic acid), the C₂₃-homolog of ursodeoxycholic acid (UDCA), showed remarkable therapeutic effects in cholestatic Mdr2 (Abcb4) (multidrug resistance protein 2/ATP-binding cassette b4) knockout mice with sclerosing/fibrosing cholangitis. In contrast to UDCA, norUDCA is ineffi