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Bile acid induced signal transductive pathways involved in regulation of cholesterol 7a-hydroxylase(CYP7a1) transcription

โœ Scribed by Seema Gupta; Richard T. Stravitz; Paul Dent; Zdravko R. Vlahcevic; Phillip B. Hylemon


Book ID
119425200
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
182 KB
Volume
118
Category
Article
ISSN
0016-5085

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The gene encoding cholesterol 7โฃ-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting induces CYP7A1 gene expression in parallel to the ind