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Regulation of oxysterol 7A-hydroxylase (CYP7b1) in primary cultures of rat hepatocytes by bile acids (BA), cholesterol (chol), cAMP and phorbol ester

โœ Scribed by Pandak, William M.; Lijun, Zhao; Hylemon, Phillip B.; Vlahcevic, Zdravko R.


Book ID
123046852
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
194 KB
Volume
118
Category
Article
ISSN
0016-5085

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The gene encoding cholesterol 7โฃ-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting induces CYP7A1 gene expression in parallel to the ind