Bicyclic Pyrazolidinone Derivatives from Diastereoselective Catalytic [3 + 3]-Cycloaddition Reactions of Enoldiazoacetates with Azomethine Imines
β Scribed by Qian, Yu; Zavalij, Peter J.; Hu, Wenhao; Doyle, Michael P.
- Book ID
- 120077308
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 418 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
Anhydrous MnBr, and CoCi, in conjunclion with chiral ephedrine iigandr effecr subslantial asymmeurc induction in cycloadducts derivedfrom methyl acrylate and imines of glycine methyl esler. CoCl, is most effeclive and gives 96% e.e. We have shown that imines of a-amino esters undergo rapid regio-and
## Abstract Highly __endoβ__diastereoselective 1,3βdipolar cycloadditions between acrylates derived from methyl (__R__)β and (__S__)βlactate, as chiral dipolarophiles, and azomethine ylides derived from glycine and Ξ±βsubstituted amino acids are described. The origins of the observed excellent stere