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ChemInform Abstract: Diastereoselective 1,3-Dipolar Cycloaddition Reactions Between Azomethine Ylides and Chiral Acrylates Derived from Methyl (S)- and (R)-Lactate — Synthesis of Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibitors.

✍ Scribed by Carmen Najera; M. de Gracia Retamosa; Jose M. Sansano; Abel de Cozar; Fernando P. Cossio

Publisher: John Wiley and Sons
Year: 2008
Weight: 32 KB
Volume: 39
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200806104

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## Abstract Highly __endo‐__diastereoselective 1,3‐dipolar cycloadditions between acrylates derived from methyl (__R__)‐ and (__S__)‐lactate, as chiral dipolarophiles, and azomethine ylides derived from glycine and α‐substituted amino acids are described. The origins of the observed excellent stere

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