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Bicyclic Nucleoside Inhibitors of Varicella—Zoster Virus: Synthesis and Biological Evaluation of 2′,3′-Dideoxy-3′-fluoro and 2′-Deoxy-xylo Derivatives

✍ Scribed by A. Carangio; C. McGuigan; G. Andrei; R. Snoeck; E. De Clercq; J. Balzarini


Publisher
John Wiley and Sons
Year
2004
Weight
55 KB
Volume
35
Category
Article
ISSN
0931-7597

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Synthesis and Biological Evaluation of a Series of 2'-Fluorinated-2',3'-dideoxy-2',3'-didehydro-(L)-nucleosides. -A general method for the synthesis of both the cis-and trans-2'-vinylfluoro containing nucleosides is presented. Among the nucleosides prepared compound (XI) displays the best biologica