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Bicyclic Analogues of d - myo -Inositol 1,4,5-Trisphosphate Related to Adenophostin A: Synthesis and Biological Activity
β Scribed by Riley, Andrew M.; Correa, Vanessa; Mahon, Mary F.; Taylor, Colin W.; Potter, Barry V. L.
- Book ID
- 126446210
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 201 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
The syntlcais from myo-inositol of two bicyelie fused ring analogues of 1D-myo-inositol 1,4,5-trispho~phate in optically active form is described. The route demonstrates the application of the recently described butane-2,3-diacetal (BDA) protecting group to inositoi chemistry, and features a novel c
Novel routes to myo-inositol 1,4,5trisphosphate and a phosphorothioate analogue involving mixed P(V) and P(III) chemistry have been developed. Phosphorylation of 2,3,6-tri-O-benzyl-myo-inositol l-[di-(2,2,2-trichloroethyl) phosphate] with bis(2,2,2-trichloroethyl) phosphorochloridate gave a mixture