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Bicyclic Analogues of d - myo -Inositol 1,4,5-Trisphosphate Related to Adenophostin A: Synthesis and Biological Activity

✍ Scribed by Riley, Andrew M.; Correa, Vanessa; Mahon, Mary F.; Taylor, Colin W.; Potter, Barry V. L.


Book ID
126446210
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
201 KB
Volume
44
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Bicyclic Analogues
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The syntlcais from myo-inositol of two bicyelie fused ring analogues of 1D-myo-inositol 1,4,5-trispho~phate in optically active form is described. The route demonstrates the application of the recently described butane-2,3-diacetal (BDA) protecting group to inositoi chemistry, and features a novel c

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Novel routes to myo-inositol 1,4,5trisphosphate and a phosphorothioate analogue involving mixed P(V) and P(III) chemistry have been developed. Phosphorylation of 2,3,6-tri-O-benzyl-myo-inositol l-[di-(2,2,2-trichloroethyl) phosphate] with bis(2,2,2-trichloroethyl) phosphorochloridate gave a mixture