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Bicyclic analogues of inositol 1,4,5-trisphosphate based upon adenophostin A

✍ Scribed by Andrew M. Riley; Barry V.L. Potter

Book ID: 104260970
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 218 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00174-4

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✦ Synopsis

The syntlcais from myo-inositol of two bicyelie fused ring analogues of 1D-myo-inositol 1,4,5-trispho~phate in optically active form is described. The route demonstrates the application of the recently described butane-2,3-diacetal (BDA) protecting group to inositoi chemistry, and features a novel construction of a dioxabieyclo[5.4.0] system using 3-chloro-2-ehloromethyl-l-propene.

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