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Biaryl Axis as a Stereochemical Relay for the Enantioselective Synthesis of Antimicrotubule Agents

✍ Scribed by Agnès Joncour; Anne Décor; Sylviane Thoret; Angèle Chiaroni; Olivier Baudoin


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
116 KB
Volume
118
Category
Article
ISSN
0044-8249

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Treatment of the dimethyl acetals of citral (1) and farnesal be subjected to a Diels-Alder reaction, which allows further synthetic elaboration. In particular, in the case of farnesal (2) with the superbase "LICKOR" in THF at low temperatures induces regioselective metallation at the allylic methyl