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BH3-only proteins: Orchestrators of apoptosis

✍ Scribed by Aisha Shamas-Din; Hetal Brahmbhatt; Brian Leber; David W. Andrews

Book ID
113486432
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
592 KB
Volume
1813
Category
Article
ISSN
0167-4889

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## Abstract Bcl‐2 family proteins play central roles in the regulation of most, if not all, apoptotic pathways, and hence this family plays a critical role in oncogenesis. The Bcl‐2 homology 3 (BH3)‐only members of this family are β€œproapoptotic,” promoting apoptosis by sensing cellular stresses: th