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BH3-only proteins in tumorigenesis and malignant melanoma

✍ Scribed by A. M. Karst; G. Li


Book ID
105758465
Publisher
Springer
Year
2006
Tongue
English
Weight
232 KB
Volume
64
Category
Article
ISSN
1420-682X

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## Abstract Bcl‐2 family proteins play central roles in the regulation of most, if not all, apoptotic pathways, and hence this family plays a critical role in oncogenesis. The Bcl‐2 homology 3 (BH3)‐only members of this family are β€œproapoptotic,” promoting apoptosis by sensing cellular stresses: th