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Beyond rituximab: The future of monoclonal antibodies in B-cell non-Hodgkin lymphoma

✍ Scribed by Manzurul A. Sikder; Jonathan W. Friedberg


Book ID
107546629
Publisher
Current Science Inc.
Year
2008
Tongue
English
Weight
260 KB
Volume
10
Category
Article
ISSN
1523-3790

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Rituximab is a chimeric anti CD-20 monoclonal antibody containing human IgG1 kappa constant regions, with murine variable regions. The anti-lymphoma effects of Rituximab are probably due to complement and antibody-dependent cell-mediated cytotoxicity, and induction of apoptosis. Phase II trials have