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CD20-specific antibody-targeted chemotherapy of non-Hodgkin’s B-cell lymphoma using calicheamicin-conjugated rituximab

✍ Scribed by John F. DiJoseph; Maureen M. Dougher; Douglas C. Armellino; Lyka Kalyandrug; Arthur Kunz; Erwin R. Boghaert; Philip R. Hamann; Nitin K. Damle

Book ID
105967182
Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
341 KB
Volume
56
Category
Article
ISSN
0340-7004

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Rituximab is a chimeric anti CD-20 monoclonal antibody containing human IgG1 kappa constant regions, with murine variable regions. The anti-lymphoma effects of Rituximab are probably due to complement and antibody-dependent cell-mediated cytotoxicity, and induction of apoptosis. Phase II trials have