Beyond hepatitis C: The anti-inflammatory role of heme oxygenase-1 in systemic infections
β Scribed by Shailendra Kapoor
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 46 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
β¦ Synopsis
is a consultant for and is on the speakers' bureau of Schering-Plough. He is also on the speakers' bureau of Roche. Dr. Luxon is a consultant for, is on the speakers' bureau of, and received grants from Schering-Plough and Roche.
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Altered expression and activity of immunomodulatory cytokines plays a major role in the pathogenesis of alcoholic liver disease. Chronic ethanol feeding increases the sensitivity of Kupffer cells, the resident hepatic macrophage, to lipopolysaccharide (LPS), leading to increased tumor necrosis facto
The heme oxygenase 1 (HO-1) gene is rapidly activated in the liver after lipopolysaccharide (LPS) treatment. Ninety minutes after LPS treatment (0.1 mg/kg, intraperitoneally) hepatic HO-1 messenger RNA (mRNA) of mice was 40 times the control value. To investigate the hepatic cellular source of the i