Between the Lines of Genetic Code. Genetic Interactions in Understanding Disease and Complex Phenotypes

✍ Scribed by Leonid Padyukov (Eds.)

• Publisher: Academic Press
• Year: 2014
• Tongue: English
• Leaves: 207
• Edition: 1
• Category: Library

✦ Synopsis

Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care.

Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases.

• Systematically integrates methods of defining and detecting gene interactions to provide an overview of the field
• Critically analyzes current methods and tools to aid researchers in integrating gene interaction studies
• Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future

✦ Table of Contents

Content:
Front-matter, Pages i,iii
Copyright, Page iv
Acknowledgments, Page xi
List of Contributors, Pages xiii-xiv, Lars Alfredsson, Camilla Bengtsson, Hector Chinoy, Robert G. Cooper, Bo Ding, David Gomez-Cabrero, Henrik Källberg, Ingrid Kockum, Ingrid E. Lundberg, Fransesco Marabita, Tomas Olsson, Leonid Padyukov, Marylyn D. Ritchie, Igor Sandalov, Klementy Shchetynsky, Jesper Tegnér
Introduction, Pages xv-xxi
Chapter One - Terminology and Definitions for Interaction Studies, Pages 3-23, Henrik Källberg, Camilla Bengtsson
Chapter Two - Reducing Dimensionality in the Search for Gene–Gene Interactions, Pages 25-37, Marylyn D. Ritchie
Chapter Three - Study Design for Interaction Analyses, Pages 39-54, Camilla Bengtsson, Henrik Källberg
Chapter Four - High-Throughput Genetic Interaction Study, Pages 55-80, Bo Ding
Part 1 - Conclusions, Pages 81-82
Chapter Five - Gene–Gene and Gene–Environment Interaction in Rheumatoid Arthritis, Pages 85-100, Leonid Padyukov, Lars Alfredsson
Chapter Six - Genetic and Environmental Risk Factors for Multiple Sclerosis—A Role for Interaction Analysis, Pages 101-114, Ingrid Kockum, Lars Alfredsson, Tomas Olsson
Chapter Seven - Gene–Gene and Gene–Environment Interactions in Defining Risk and Spectrum of Phenotypes in Idiopathic Inflammatory Myopathies, Pages 115-132, Robert G Cooper, Hector Chinoy, Ingrid E. Lundberg
Part 2 - Conclusions, Pages 133-134
Chapter Eight - Functional Studies of Gene–Gene Interaction of Autoimmune Diseases, Pages 137-150, Klementy Shchetynsky, Leonid Padyukov
Chapter Nine - Genetic Vectors Approach in a Study of Fine Structure of Interaction Between Risk Haplotype of HTR2A and HLA-DRB1 Shared Epitope Alleles in Rheumatoid Arthritis, Pages 151-174, Igor Sandalov, Leonid Padyukov
Chapter Ten - Network Biology Empowering Detection and Understanding of Interactions Between Genetic Factors in Development of Complex Phenotypes, Pages 175-194, Jesper Tegnér, Francesco Marabita, David Gomez-Cabrero
Part 3 - Conclusions, Page 195, Leonid Padyukov
Index, Pages 197-203