Beta-lactams derived from the reaction of phenanthridines and 11H-dibenzo[b,e]azepin-11-one with phenylvaleryl chloride. Synthesis of fused analogs of the cholesterol absorption inhibitor Sch 48461

✍ Scribed by Adriano Afonso; Stuart B Rosenblum; Mohindar S Puar; Andrew T McPhail

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 230 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01648-7

✦ Synopsis

Phenanthridines 4 and the l lH-dibenzo[b,e]azepin-I l-one 17 were used as the imine components in the ketene-imine ]3-1actam synthesis to provide the fused tetracyclic [3-1actams 7, 8 and 18.