Beta-globin gene cluster haplotype distribution in five Brazilian Indian tribes

✍ Scribed by Lia R. M. Bevilaqua; Vanessa S. Mattevi; Gisele M. Ewald; Francisco M. Salzano; Carlos E. A. Coimbra JR.; Ricardo V. Santos; Mara H. Hutz

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 544 KB
• Volume: 98
• Category: Article
• ISSN: 0002-9483
• DOI: 10.1002/ajpa.1330980402

✦ Synopsis

Haplotypes derived from five polymorphic restriction sites in the beta-globin gene cluster were investigated in 139 individuals from five different Brazilian Indian tribes by the polymerase chain reaction (PCR).

Eight haplotypes were identified. Haplotypes 2 (+ ----1 and 6 (-+ + -+)

were the most frequent and were common to all tribes. Their prevalences ranged from 60% to 93% and from 3% to 18%, respectively. Average heterozygosity measured by the Gini-Simpson index is markedly reduced among these Brazilian Indians when compared with Europeans (56%), but much less (8%) in relation to Asiatics, suggesting the absence of a n important bottleneck effect in the early colonization of South America. The coefficient of gene differentiation (GST') was estimated as 0.082 among six Brazilian Indian tribes, but when only three Tupi-Monde-speaking tribes were considered, this estimate was reduced to 0.030. o 1995 Wiley-Liss, Inc.