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Berberine/γ-Cyclodextrin Inclusion Structure Studied by 1H-NMR Spectroscopy and Molecular-Dynamics Calculations

✍ Scribed by Miyoko Kamigauchi; Narumi Kanbara; Makiko Sugiura; Kinuko Iwasa; Hirofumi Ohishi; Toshimasa Ishida

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
161 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

To understand the increased solubility and decreased bitter taste of berberine, a clinically important isoquinoline alkaloid, in the presence of cyclodextrins, the interaction with γ‐cyclodextrin (γ‐CD) in aqueous solution was studied by a combination of ^1^H‐NMR analyses and molecular‐dynamics calculations. The proposed complexation mode of berberine by γ‐CD could explain the increased solubility in water. No difference in germicidal activity between berberine alone and its inclusion complex with γ‐ or β‐CD was observed, which is important to further develop the pharmacological application of berberine.

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