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Benzylisoquinoline compounds inhibit the ability of calmodulin to activate cyclic nucleotide phosphodiesterase

✍ Scribed by Zhuo-Yi Hu; Shao-Lin Chen; Zhi-Gi Hao; Wen-Long Huang; Si-Xun Peng

Book ID
113388259
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
277 KB
Volume
1
Category
Article
ISSN
0898-6568

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We studied effects of calmodulin antagonists on osteoclastic activity and calmodulin-dependent HCl transport. The results were compared to effects on the calmodulin-dependent phosphodiesterase and antagonistcalmodulin binding affinity. Avian osteoclast degradation of labeled bone was inhibited ,40%