Inhibition of calmodulin-activated cyclic nucleotide phosphodiesterase: Multiple binding-sites for tricyclic drugs on calmodulin
โ Scribed by C. Hugh Reynolds; Paul T.J. Claxton
- Book ID
- 115776170
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 359 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0006-2952
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We studied effects of calmodulin antagonists on osteoclastic activity and calmodulin-dependent HCl transport. The results were compared to effects on the calmodulin-dependent phosphodiesterase and antagonistcalmodulin binding affinity. Avian osteoclast degradation of labeled bone was inhibited ,40%
The effect of regucalcin, a calcium-binding protein isolated from rat liver cytosol, on Ca2+/calmodulin-dependent cyclic nucleotide (AMP) phosphodiesterase activity in rat liver cytosol was investigated. The addition of Ca2+ (50 microM) and calmodulin 160 U/ml in the enzyme reaction mixture caused a