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Benzyl Alcohol Attenuates Acetaminophen-Induced Acute Liver Injury in a Toll-Like Receptor-4 Dependent Pattern in Mice

✍ Scribed by Luciano, J.A.; Cai, C.; Kautza, B.; Whelan, S.; Stratimirovic, S.; Billiar, T.R.; Zuckerbraun, B.S.


Book ID
122376563
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
66 KB
Volume
186
Category
Article
ISSN
0022-4804

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Chronic alcohol administration increases gut-derived endotoxin in the portal blood, which activates Kupffer cells and causes liver injury. Mice (C3H/HeJ) with mutations in toll-like receptor 4 (TLR4) are hyporesponsive to endotoxin. To test the hypothesis that TLR4 is involved in early alcohol-induc