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Benzodiazepines and their metabolites: Relationship between binding affinity to the benzodiazepine receptor and pharmacological activity

✍ Scribed by Iwao Nakatsuka; Hiroshi Shimizu; Yukio Asami; Terufumi Katoh; Akira Hirose; Akira Yoshitake


Book ID
118340889
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
300 KB
Volume
36
Category
Article
ISSN
0024-3205

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Preparative and analytical separation of
✍ Dr. Gottfried Blaschke; Georg Hempel; Walter E. MΓΌller πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 276 KB

We report the preparative separation of rac-zopiclone using malic acid as the resolving agent. Furthermore, two different methods for the analytical determination of zopiclone enantiomers by HPLC on chiral stationary phases are described. The benzodiazepine receptor binding of the isolated enantiome