Benzocondensed derivatives as rigid analogues of the μ-opioid agonist 3(8)-cinnamyl-8(3)-propionyl-3,8-diazabicyclo[3.2.1]octanes: synthesis, modeling, and affinity
✍ Scribed by G Cignarella; D Barlocco; P Vianello; S Villa; G.A Pinna; P Fadda; W Fratta; L Toma; S Gessi
- Book ID
- 114019429
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 184 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0014-827X
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A series of trimethyipiperazine derivatives, structurally related to the Ix-agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane, have been synthesized and teswxl in binding studies, using 3H-DAMGO as Ix-selective ligand. Their different affinity towards Ix-opioid receptors has been interpre
Trimethylpiperazines as Monocyclic Analogues of the . mu.-Opioid Agonist 3,8-Diazabicyclo(3.2.1)octanes: Synthesis, Modeling, and Activity. -The trimethylpiperazine derivatives (IV)-(VII) are tested in binding studies for µ-opioid receptors. Their different affinity towards . mu.-opioid receptors i