𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice

✍ Scribed by KAPITULNIK, JAIME; LEVIN, WAYNE; CONNEY, ALLAN H.; YAGI, HARUHIKO; JERINA, DONALD M.

Book ID
109704300
Publisher
Nature Publishing Group
Year
1977
Tongue
English
Weight
326 KB
Volume
266
Category
Article
ISSN
0028-0836

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Synthesis of 13C2-benzo[a]pyrene and its
Synthesis of 13C2-benzo[a]pyrene and its 7,8-dihydrodiol and 7,8-dione implicated as carcinogenic metabolites
✍ Chongzhao Ran; Daiwang Xu; Qing Dai; Trevor M. Penning; Ian A. Blair; Ronald G. πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 French βš– 175 KB

Synthesis of the 13 C 2 -labelled analogues of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene and its active metabolites is described. The method entails Pd-catalyzed Suzuki-Miyaura coupling of a naphthalene boronic acid with 2-bromobenzene-1,3-dialdehyde followed by Wittig reaction

Ellagic acid toxicity and interaction wi
Ellagic acid toxicity and interaction with benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol in human bronchial epithelial cells
✍ Robert W. Teel; Merrill S. Babcock; Rakesh Dixit; Gary D. Stoner πŸ“‚ Article πŸ“… 1986 πŸ› Springer 🌐 English βš– 606 KB

Ellagic acid, a plant phenol present in various foods consumed by humans, has been reported to have both anti-mutagenic and anticarcinogenic potential. To evaluate the potential anti-carcinogenic property of ellagic acid, we tested its effects on the toxicity of benzo [aj~yrene and benzo[af~yrene, 7

Activation of benzo(a)pyrene-7,8-dihydro
Activation of benzo(a)pyrene-7,8-dihydrodiol in rat uterus: Anin vitro study
✍ Byczkowski, Janusz Z. ;Kulkarni, Arun P. πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 673 KB

Peroxidatic metabolism of benzo( a ) pyrene-7,S-dihydrodiol by calcium containing extracts of rat uteri was investigated. Covalently bound and soluble metabolites of benzo( a)pyrene-7,S-dihydrodiol were quantitated by radiometry and high performance liquid chromatography, respectively. 1. Uterine ex

The role of 12 cDNA-expressed human, rod
The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7, 8-dihydrodiol
✍ Magang Shou; Kenneth R. Korzekwa; Charles L Crespi; Frank J. Gonzalez; Harry V. πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 881 KB

## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino

Differential c-myc expression profiles i
Differential c-myc expression profiles in normal human bronchial epithelial cells following treatment with benzo[a]pyrene, benzo[a]pyrene-4,5 epoxide, and benzo[a]pyrene-7,8-9,10 diol epoxide
✍ Wanda R. Fields; Joseph G. Desiderio; Randi M. Leonard; Ellen E. Burger; Buddy G πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 138 KB

## Abstract Bronchial epithelial cells are often exposed to airborne mutagens that have the potential to induce genetic changes involved in the development of lung cancer. Although lung tumors often display alterations in the expression of oncogenes and/or tumor suppressor genes, the role of specif