𝔖 Bobbio Scriptorium
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Benzannelation alters the rate limiting step in enediyne cycloaromatization

✍ Scribed by Toshio Kaneko; Miki Takahashi; Masahiro Hirama

Book ID
104260903
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
192 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The rate-limiting step in the Bergman reaction was changed from cyclization to hydrogen-abstraction by benzannelation. This effect should be attributed to the faster rate of the retro-Bergman cyclization and/or the slower rate of hydrogen abstraction by the aromatic ring condensed 1,4-didehydrobenzene intermediate.

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Rate-limiting step in the progression of
Rate-limiting step in the progression of mouse breast tumors
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## Abstract Age‐specific incidence curves of mouse breast cancer suggest a rate‐limiting step in tumor progression one step prior to overt cancer and the withdrawal prior to middle life of a critical etiological condition (hormonal?) for one or more of the earlier steps in the oncogenic sequence.